The Gadsden area is served by a main line of Norfolk Southern Railways and by OmniTRAX, the largest private railroad operator in North America.
Gadsden's Northeast Alabama Regional Airport is an uncontrolled field. It has a main runway of 6,802 x 150 feet (2,073 x 46 meters), a secondary runway of 4,806 x 100 feet (1,465 x 30 meters), and a Category 1 Instrument Landing System. On average, there are 300 takeoffs and landings per week, counting touch-and-gos. It is general aviation traffic, including corporate jets, about 75% of which is transient. For communications, navaids, runway specifications and more details, click here.
The Port of Guntersville is a bulk freight transfer terminal located approximately 35 miles/56 kilometers northwest of Gadsden via U.S. Highway 431, and is served from Gadsden by the Alabama & Tennessee River Railway. It is at river mile 358.8 on the Tennessee River, which connects to the Tennessee-Tombigbee Waterway and terminates at the Port of Mobile. Barge and tow companies are listed here.